District Five headquarters are located at the Texas A&M AgriLife Research & Extension Center in Overton.
| District Five County Extension Phone Numbers |
|
| Anderson County | (903) 723-3735 |
| Angelina County | (409) 632-8239 |
| Cherokee County | (903) 683-5416 |
| Gregg County | (903) 236-8428 |
| Harrison County: | (903) 935-8414 (903) 935-4836 |
| Henderson County: | (903) 675-6130 |
| Houston County | (409) 544-3255 |
| Jasper County | (409) 384-3721 |
| Marion County: | (903) 665-2421 |
| Nacogdoches County | (409) 560-7711 |
| Newton County: | (409) 379-4831 |
| Panola County | (903) 693-0380 |
| Polk County | (409) 327-6828 |
| Rusk County | (903) 657-0376 |
| Sabine County | (409) 787-3752 |
| San Augustine County | (409) 275-3644 |
| Shelby County | (409) 598-7744 |
| Smith County | (903) 590-2980 |
| Trinity County | (409) 642-1421 |
| Tyler County | (409) 283-8284 |
| Upshur County | (903) 843-4019 |
| Wood County | (903) 763-2924 |